دانلود مقالات ISI درباره 4E-Bp + ترجمه فارسی

کمبود گلیسرول 3-فسفات دهیدروژناز 1 باعث متابولیسم آمینواسیدهای جبرانی در طی ناشتا در موش می شود

Glycerol-3-phosphate dehydrogenase 1 deficiency induces compensatory amino acid metabolism during fasting in mice

Keywords: Glycerol; BALB/cHeA; Gluconeogenesis; Glycogenic amino acid; ALT; alanine amino transferase; ATGL; adipocyte triglyceride lipase; BCAA; branched chain amino acids; DHAP; dihydroxyacetone phosphate; FoxO; forkhead box O; GPD; glycerol-3-phosphate dehydroge

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

فعال سازی ماتریکس مؤثر است که فعالیت میتوکندری را افزایش می دهد و باعث کاهش چربی رحمی در موش می شود

Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice

Keywords: 4E-BP; eukaryotic initiation factor 4E-binding protein;; ATscKO; Tsc1Lox/Lox adiponectin-cre+/− mice; ATscWT; Tsc1Lox/Lox adiponectin-cre−/− mice; C/EBP; CCAAT/enhancer-binding protein; CYC1; cytochrome c-1; DEPTOR; DEP domain-containing mTOR-intera

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

هدف درمان درمانی هیپوکسی و فاکتور القایی قابل تشخیص هیپوکسیا در مولتیپل میلوما است

Therapeutic targeting of hypoxia and hypoxia-inducible factor 1 alpha in multiple myeloma

Keywords: BM; bone marrow; CAD; carboxyl-terminal transactivation domain; CBP; CREB binding protein; CXCL12; C-X-C motif chemokine 12; 4E-BP; 4E binding protein; ECs; endothelial cells; eIF-4F; eukaryotic initiation factor 4F; FIH-1; factor inhibiting HIF; HIFs; hy

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

فاکتور القای هیپوکسی 1 و نقش آن در سرطان زایی ویروس

Hypoxia-inducible factor 1 and its role in viral carcinogenesis

Keywords: 4E-BP; 4E binding protein; AP-1; activator protein-1; Ad-AH; EBV-negative adenocarcinoma cell line; Akt; serine/threonine kinase; ARNT; aryl hydrocarbon receptor nuclear translocator; ATP/ADP; adenosine tri- or diphosphate; CAIX and CAXII; carbonic anhydr

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas

Keywords: 4E-BP; 4E binding protein; AKT; v-akt murine thymoma viral oncogene homolog; BCC; basal cell carcinoma; BCNS; basal cell nevus syndrome; CCND1; cyclin D1; GLI; glioma-associated oncogene homolog; HEK; human embryonic kidney; ITRA; itraconazole; mTOR; mamm

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Ecdysteroidogenesis and development in Heliothis virescens (Lepidoptera: Noctuidae): Focus on PTTH-stimulated pathways

Keywords: PG; prothoracic gland; BE; brain equivalent; PTTH; prothoracicotropic hormone; MAPK; mitogen-activated protein kinase; PI3K; phosphoinositide 3-kinase; Akt; protein kinase B; TOR; target of rapamycin; EIA; enzyme immunoassay; 4E-BP; translational represso

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Kinetic analyses of phosphorylated and non-phosphorylated eIFiso4E binding to mRNA cap analogues

Keywords: eIF; eukaryotic initiation factor; eIFiso4Ep; phosphorylated eukaryotic initiation factor; PABP; poly(A) binding protein; 4E-BP; eIF4E-binding protein; Ant-m7GTP; anthraniloyl 7-methyl-guanosine triphosphate; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesu

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Signaling involved in PTTH-stimulated 4E-BP phosphorylation in prothoracic gland cells of Bombyx mori

Keywords: Ecdysone; Prothoracic gland; Signal transduction; 4E-BP; AMPK;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

mTORC1 inhibition with rapamycin exacerbates adipose tissue inflammation in obese mice and dissociates macrophage phenotype from function

Keywords: 4E-BP; eIF4E binding protein; AUC; area under the curve; BMDM; bone marrow-derived macrophages; BSA; bovine serum albumin; CLEC10a; C-type lectin domain family 10 member A; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinases; FACS; Fluo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewReappraisal to the study of 4E-BP1 as an mTOR substrate - A normative critique

Keywords: mTOR; 4E-BP; eIF4E; Rapamycin; Post-translational modification;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease

Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

The estrogen metabolite 2-methoxyestradiol regulates eukaryotic initiation factor 4E (eIF4E) and inhibits protein synthesis in MG63 osteosarcoma cells

Keywords: 2-Methoxyestradiol; 4E-BP; Estrogen metabolite; eIF4E; Osteosarcoma

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation

Keywords: Cancer; eIF4E; Protein synthesis; mRNA translation; Cap-binding inhibitor; eIF; eukaryotic translation initiation factor; 4E-BP; eF4E-binding protein; FP; fluorescence polarisation; m7G; N7-methyl guanosine; RRL; rabbit reticulocyte lysate;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats

Keywords: STZ; streptozotocin; PDN; painful diabetic neuropathy; DRG; dorsal root ganglion; mTOR; mammalian target of rapamycin; S6K; ribosomal protein S6 kinase; 4E-BP; eukaryotic initiation factor 4E (eIF4E) binding protein; IR; insulin receptor; IRS-1; insulin r

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

The race to decipher the top secrets of TOP mRNAs

Keywords: TOP mRNAs; S6K; 4E-BP; TIA-1; LARP1; miR-10a

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Metformin inhibits age-related centrosome amplification in Drosophila midgut stem cells through AKT/TOR pathway

Keywords: 4E-BP; eukaryotic translation initiation factor 4E-binding protein; 8-oxo-dG; 8-oxo-2′-deoxyguanosine; AMPK; 5′ AMP-activated protein kinase; EBs; enteroblasts; ECs; enterocytes; EEs; enteroendocrine cells; EGFR; epidermal growth factor receptor; IGF1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Keywords: AMPK; AMP-activated protein kinase; EGCG; epigallocatechin-3-gallate; CG; cardiac glycoside; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; FAS; fatty acid synthase; FoxO; forkhead box O; GLUT; glucose transporter; HK2; hexokinase-2; HIF-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

MYC and metabolism on the path to cancer

Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

mTORC1 signaling controls multiple steps in ribosome biogenesis

Keywords: 4E-BP; eIF4E-binding protein; 5′-TOP; 5′-terminal oligopyrimidine tract; BOP1; block of proliferation 1; eEF2; eukaryotic elongation factor; eEF2K; eEF2 kinase; eIF; eukaryotic initiation factor; ERK; extracellular ligand-regulated kinase; MEK; MAP an

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1

Keywords: PrPC; normal cellular prion protein; PrPSc; disease-associated prion protein; GT1-1 cells; immortalized hypothalamic gonadotropin-releasing hormone neurons; BDNF; brain-derived neurotrophic factor; MEK; mitogen-activated protein kinase kinase; ERK; extrac

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The development of CNS-active LRRK2 inhibitors using property-directed optimisation

Keywords: PD; Parkinson's disease; LRRK2; leucine-rich repeat kinase 2; DLP1; dynamin-like protein 1; FOXO1; forkhead box transcription factor; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; SBDD; structure-based drug design; HTS; high throughput

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Intracerebroventricular administration of ouabain, a Na/K-ATPase inhibitor, activates mTOR signal pathways and protein translation in the rat frontal cortex

Keywords: 4E-BP; eukaryotic translation initiation factor 4E binding protein; aCSF; artificial cerebrospinal fluid; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; DAPI; 4′,6′-diamidino-2-phenylindole; EGFR; epidermal growth factor recepto

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs

Keywords: 4E-BP; eIF4E-binding protein; BMH; branched multiple hairpins; CrPV; cricket paralysis virus; CSFV; Classical Swine Fever Virus; DIS; dimerization site; eIF; eukaryotic initiation factor; EMCV; encephalomyocarditis virus; FMDV; foot-and-mouth-disease viru

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

Keywords: PD; Parkinson disease; LRRK2; leucine-rich repeat kinase 2; ROC; Ras of complex proteins; TH; tyrosine hydroxylase; PAL; protocerebral antero lateral; PAM; paired anterolateral medial; PPM; protocerebral posterior medial; DA; dopamine; IP; immunoprecipita

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori

Keywords: Bombyx mori; Prothoracic gland; PI3K; Akt; TOR signaling; PTTH; 4E-BP; S6K; ERK;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ΔRG mouse model of tuberous sclerosis complex

Keywords: 4E-BP; eIF4E binding protein; ACSF; artificial cerebrospinal fluid; CMV; cytomegalovirus; FXS; fragile X syndrome; GAP; GTPase-activating protein; GDP; guanosine diphosphate; GTP; guanosine triphosphate; mTORC1; mammalian target of rapamycin complex 1; Rh

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and function of the second eIF4E-binding region in N-terminal domain of eIF4G: Comparison with eIF4E-binding protein

Keywords: 4E-BP; eIF4E-binding protein; CD; circular dichroism; DTT; dithiothreitol; eIF4E; eukaryotic initiation factor 4E; HEPES; 2-[4-(2-hydroxyethyl)-1-piperazinyl] ethanesulfonic acid; ITC; isothermal titration calorimetry; MD; molecular dynamics; m7GTP; 7-met

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

A collection of caged compounds for probing roles of local translation in neurobiology

Keywords: Caged; Optical; Photo-control; Protein synthesis; Translation; Rapamycin; 4E-BP; Anisomycin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster

Keywords: CR, calorie restriction; DR, dietary restriction; DN, dominant-negative; Dmp53, Drosophila p53; wt, wild type; IIS, insulin/insulin-like growth factor signaling; dILP, Drosophila insulin-like peptidep53; Dmp53; Calorie restriction; TOR; 4E-BP; Thor; Droso

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

TOR signaling is required for amino acid stimulation of early trypsin protein synthesis in the midgut of Aedes aegypti mosquitoes

Keywords: Rapamycin; RNAi; 4E-BP; p70S6 Kinase; Translational control; Blood meal metabolism

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Altered protein synthesis is a trigger for long-term memory formation

Keywords: Translation; Protein kinase; Learning; PKM-ζ; Positive feedback; Knockout mouse; mTOR; GCN2; eIF2; 4E-BP; S6K

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen

Keywords: AEC; aortic endothelial cell; bFGF; basic fibroblast growth factor; cAMP; cyclic adenosine 3′,5′-monophosphate; CKI; cyclin-dependent kinase inhibitor; CRY1; cryptochrome 1; CYP3A6; cytochrome p450 oxidase 3A6; DEC1; deleted in esophageal cancer 1; 4E

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods

Keywords: DTT; dithiothreitol; eIF4E; eukaryotic initiation factor 4E; 4E-BP; eIF4E binding protein; MD; molecular dynamics; m7G; 7-methyl guanine; m7GDP; 7-methylguanosine 5′-diphosphate; m7GTP; 7-methylguanosine 5′-triphosphate; m7GpppA; P1-7-methylguanosine-

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2005 سفارش ترجمه

BDNF function in adult synaptic plasticity: The synaptic consolidation hypothesis

Keywords: ACD; actinomycin D; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor; Arc; activity-regulated cytoskeleton-associated protein; Arg; activity-regulated gene; BDNF; brain-derived neurotrophic factor; BDNF-LTP; brain-derived neuro

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2005 سفارش ترجمه