کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5739162 | 1615360 | 2017 | 19 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microglial phenotypes in Parkinson's disease and animal models of the disease
ترجمه فارسی عنوان
فنوتیپ های میکروگلالی در بیماری پارکینسون و مدل های حیوانی بیماری است
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کلمات کلیدی
IP-10MCP-1COX1cox2LRRK26-OHDAIFN-γTLRMHC-IIMPTPIL-12MIP-1βFcγRIINT-proCNPTNFTGF-βRNF11EGFIL-16-HydroxydopamineLPSIL-61-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridineNFκB - NFKBFACIT - آیاNeuroinflammation - التهاب عصبیImmune - ایمنیinterferon-gamma - اینترفرون گاماinterleukin-12 - اینترلوکین -12interleukin-6 - اینترلوکین ۶Transforming growth factor β - تبدیل فاکتور رشد βsubstantia nigra - توده سیاهNeurodegeneration - تولید نوروژنیکPositron emission tomography - توموگرافی گسیل پوزیترونleucine-rich repeat kinase 2 - تکرار کیناز 2 غنی از لوسینToll-like receptor - تیالآرDopamine - دوپامینBBB - سد خونی مغزیCerebral Spinal Fluid - سیالات مغزی نخاعیcyclo-oxygenase 2 - سیکلو اکسیژناز 2epidermal growth factor - عامل رشد اپیدرمیtumor necrosis factor - فاکتور نکروز تومورnuclear factor kappa beta - فاکتور هسته ای کاپا بتاlipopolysaccharide - لیپوپلی ساکاریدBlood-brain barrier - مانع خون مغزیmacrophage inflammatory protein-1β - ماکروفاژ التهابی پروتئین 1βCSF - مایع مغزی نخاعیNeuroprotection - محافظت نورونی یا محافظت از عصبHospital Anxiety and Depression Scale - مقیاس اضطراب و افسردگی بیمارستانMicroglia - میکروگلیاهاHADS - هاتParkinson’s - پارکینسونPET - پتMonocyte chemotactic protein-1 - پروتئین chemotactic monocyte-1C reactive protein - پروتئین واکنشی CCRP - پروتئین واکنشی سی یا سی. آر. پی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Over the last decade the important concept has emerged that microglia, similar to other tissue macrophages, assume different phenotypes and serve several effector functions, generating the theory that activated microglia can be organized by their pro-inflammatory or anti-inflammatory and repairing functions. Importantly, microglia exist in a heterogenous population and their phenotypes are not permanently polarized into two categories; they exist along a continuum where they acquire different profiles based on their local environment. In Parkinson's disease (PD), neuroinflammation and microglia activation are considered neuropathological hallmarks, however their precise role in relation to disease progression is not clear, yet represent a critical challenge in the search of disease-modifying strategies. This review will critically address current knowledge on the activation states of microglia as well as microglial phenotypes found in PD and in animal models of PD, focusing on the expression of surface molecules as well as pro-inflammatory and anti-inflammatory cytokine production during the disease process. While human studies have reported an elevation of both pro- or anti-inflammatory markers in the serum and CSF of PD patients, animal models have provided insights on dynamic changes of microglia phenotypes in relation to disease progression especially prior to the development of motor deficits. We also review recent evidence of malfunction at multiple steps of NFκB signaling that may have a causal interrelationship with pathological microglia activation in animal models of PD. Finally, we discuss the immune-modifying strategies that have been explored regarding mechanisms of chronic microglial activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 155, August 2017, Pages 57-75
Journal: Progress in Neurobiology - Volume 155, August 2017, Pages 57-75
نویسندگان
Valerie Joers, Malú G. Tansey, Giovanna Mulas, Anna R. Carta,