کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4353791 1298502 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Somatostatin, Alzheimer's disease and cognition: An old story coming of age?
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Somatostatin, Alzheimer's disease and cognition: An old story coming of age?
چکیده انگلیسی

In mammalian brain, the somatostatin (SRIF: somatotropin release-inhibiting factor) family is composed of two peptides: SRIF and cortistatin (CST), which interact with five different receptor subtypes, sst1–5. This review summarizes the properties of these receptors, the involvement of somatostatinergic systems in Alzheimer's disease (SRIF/acetylcholine (Ach), SRIF/amyloid β peptides, and SRIF/tau interactions) and their role in cognition from early studies using cysteamine as an SRIF depleting substance to the use of subtype selective analogues and knockout mice, and modulation of synaptic plasticity. The current SRIF story illustrates how cognition and emotion are intimately integrated in brain function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neurobiology - Volume 89, Issue 2, October 2009, Pages 153–161
نویسندگان
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