کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4355080 1615571 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
No longer falling on deaf ears: Mechanisms of degeneration and regeneration of cochlear ribbon synapses
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
پیش نمایش صفحه اول مقاله
No longer falling on deaf ears: Mechanisms of degeneration and regeneration of cochlear ribbon synapses
چکیده انگلیسی


• Cochlear ribbon synapses are required for rapid and reliable neurotransmission.
• Degeneration of ribbon synapses is a common pathology in sensorineural hearing loss.
• Strategies promoting regeneration of ribbon synapses are discussed.

Cochlear ribbon synapses are required for the rapid and precise neural transmission of acoustic signals from inner hair cells to the spiral ganglion neurons. Emerging evidence suggests that damage to these synapses represents an important form of cochlear neuropathy that might be highly prevalent in sensorineural hearing loss. In this review, we discuss our current knowledge on how ribbon synapses are damaged by noise and during aging, as well as potential strategies to promote ribbon synapse regeneration for hearing restoration.This article is part of a Special Issue entitled .

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 329, November 2015, Pages 1–10
نویسندگان
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