Intrinsic modulators of auditory thalamocortical transmission

► Group II mGluRs in layer 4 mediate a reduction in thalamocortical (TC) EPSP/Cs. ► Pre- and post-synaptic mechanisms are involved in the attenuation of TC EPSP/Cs. ► Group II mGluRs may autoregulate TC transmission via gating or gain control.