Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities

► How to use NGS technologies for studies on epidemiological scales is still an unsolved issue. ► Gene capture combined with NGS allows much larger number of samples to be examined. ► Therefore, targeted gene enrichment followed by NGS may provide a solution. ► Such an approach promises to bring a paradigm shift to studies of genetics of deafness. ► A review on principles and applications of gene enrichment and NGS technologies is presented.