Effects of electrical stimulation on the acoustically evoked auditory-nerve response in guinea pigs with a high-frequency hearing loss

Criteria for cochlear implantation keep expanding and people with substantial residual low-frequency hearing are considered candidates for implantation nowadays. Therefore, electro-acoustical stimulation in the same ear (EAS) is receiving increasing interest. We have investigated the effects of intracochlear electrical stimulation on acoustically evoked auditory-nerve activity, using a forward masking paradigm. The stimulation electrode was placed in the basal turn of the cochlea. Compound action potential (CAP) recordings were performed in guinea pigs with severe high-frequency hearing loss and in normal-hearing control animals. In normal-hearing animals, electrical stimulation generally suppressed CAPs, especially at high acoustic frequencies (8 and 16 kHz) and low sound levels. At low frequencies (0.5 and 1 kHz), suppression was observed only at high sound levels. In animals with a high-frequency hearing loss, suppression of CAPs at low frequencies was substantially less compared to control animals, even at high current levels and temporal overlap of acoustic and electric stimuli. Hence, effects of electrical stimulation substantially differed between normal-hearing animals and animals with a high-frequency hearing loss. These findings stress the need for a proper animal model when investigating EAS. We conclude that in case of high-frequency loss, the basal part of the cochlea can be stimulated electrically with little effect on responses to low-frequency acoustic stimuli.

Research highlights
► Auditory-nerve responses to combined electro-acoustical stimulation were studied.
► In normal hearing animals electrical stimulation of the cochlear base suppressed tone-evoked responses.
► Suppression of low-frequency evoked responses was found only at high sound levels.
► In animals with a high-frequency hearing loss, suppression was less than normal.
► Electrical stimulation of the cochlear base has little effect on low-frequency evoked responses.