Effect of capsaicin on potassium conductance and electromotility of the guinea pig outer hair cell

► Capsaicin is a potent blocker of OHC K conductances (IK and IK,n). ► Capsaicin substantially alters OHC nonlinear capacitance, the signature of electromotility. ► No evidence of the characteristic TRPV-1 current in isolated OHC.