Long term effects of BAPTA in scala media on cochlear function

If the effect of BAPTA, in lowering endolymphatic Ca2+ concentration, is restricted to the destruction of tip links, as has been shown in many other preparations, then these results suggest that this effect has permanent consequences, either because the tip links failed to regenerate or because their destruction precipitated the degeneration of OHCs. These results may have a bearing on the mechanisms behind permanent threshold shift.