کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4368981 | 1616723 | 2008 | 5 صفحه PDF | دانلود رایگان |
Cell-to-cell communications in bacteria mediated by small diffusible molecules termed as autoinducers (AI) are known to influence gene expression and pathogenicity. Oligopeptides and N-acylhomoserine lactones (AHL) are major AI molecules involved in intra-specific communication in Gram-positive and Gram-negative bacteria respectively, whereas boronated-diester molecules (AI-2) are involved in inter-specific communication among both Gram-positive and Gram-negative bacteria. Naturally occurring furocoumarins from grapefruit showed > 95% inhibition of AI-1 and AI-2 activities based on the Vibrio harveyi based autoinducer bioassay. Grapefruit juice and furocoumarins also inhibited biofilm formation by Escherichia coli O157:H7, Salmonella typhimurium and Pseudomonas aeruginosa. These results suggest that grape fruit juice and furocoumarins could serve as a source to develop bacterial intervention strategies targeting microbial cell signaling processes.
Journal: International Journal of Food Microbiology - Volume 125, Issue 2, 15 July 2008, Pages 204–208