Ox40L-Ox40 pathway plays distinct roles in regulating Th2 responses but does not determine outcome of cutaneous leishmaniasis caused by Leishmania mexicana and Leishmania major

- First study to examine the role of Ox40L-Ox40 in L. mexicana infection.
- Ox40L pathway does not induce Th2 responses in experimental L. mexicana infection.
- Ox40L-Ox40 co-stimulation is not critical for susceptibility to L. mexicana.
- Ox40L-Ox40 promotes Th2 response but does not affect outcome of L. major infection.