کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371485 1302524 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Trichinella spiralis: Modulation of experimental autoimmune encephalomyelitis in DA rats
چکیده انگلیسی

Helminth infection has a potent systemic immunomodulatory effect on the host immune response, which also affects the development of autoimmune diseases. We investigated the dose-dependent influence of Trichinella spiralis infection on experimental autoimmune encephalomyelitis (EAE). Our model of concomitant T. spiralis infection and EAE demonstrates that established infection of Dark Agouti (DA) rats with the parasite causes amelioration of the clinical course of induced EAE in a dose-dependent way. Infection with T. spiralis L1 stage muscle larvae (TSL1) reduced the severity of the autoimmune disease as judged by lower maximal clinical score, cumulative index, duration of illness and degree of mononuclear cell infiltration in T. spiralis infected animals compared to control, EAE-induced group. This study provides a valuable model of worm infection to investigate helminth-induced regulatory mechanisms for optimal benefit to the host.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 118, Issue 4, April 2008, Pages 641–647
نویسندگان
, , , , , ,