کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371618 1302532 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel in vitro and in vivo models to study central nervous system infections due to Acanthamoeba spp.
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Novel in vitro and in vivo models to study central nervous system infections due to Acanthamoeba spp.
چکیده انگلیسی

Acanthamoeba granulomatous encephalitis is a serious human infection with fatal consequences. The most distressing aspect of Acanthamoeba granulomatous encephalitis is the limited improvement in mortality. The underlying neurobiology is at present not well understood and treatment options are often of limited efficacy. There is therefore a real need to obtain more knowledge regarding the pathogenesis and pathophysiology of Acanthamoeba granulomatous encephalitis and to develop new chemotherapeutic approaches. However, the difficulties in using mammalian models to study this infection have hindered our search for therapeutic interventions. Recent availability of the blood–brain barrier, in vitro and use of locust as an in vivo model will undoubtedly allow us to investigate disease pathogenesis, mechanisms of parasite traversal across the blood–brain barrier and new drug therapies. It is argued that the models described here can offer several advantages in terms of speed, cost, technical convenience, and ethical acceptance. Furthermore, they are extremely valuable tools to discriminate molecules participating from both sides of the host–parasite interaction and will generate potentially useful leads in the identification of new potential drugs, as well as testing drug toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 126, Issue 1, September 2010, Pages 69–72
نویسندگان
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