کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4371751 | 1302539 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-term feeding a high-fat diet causes histological and parasitological effects on murine schistosomiasis mansoni outcome
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
انگل شناسی
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چکیده انگلیسی
This study investigated whether long-term feeding a high-fat diet (HFC) has an effect on schistosomiasis mansoni outcome compared to standard chow diet (SC). Swiss Webster female mice (3 wk old) fed each diet over 5 months, and then were infected with 50 Schistosoma mansoni cercariae. Their nutritional status was assessed by monitoring growth rates twice a week and measuring serum levels of lipoproteins. Mice were euthanised 63 days after infection. Parasitological and liver histological analyses were performed. The levels of TC, HDL-C and LDL-C, fecal and tissue schistosome eggs were statistical different (p < 0.05) between groups. Livers from HFC mice showed exudative, exudative/exudative-productive, exudative-productive and productive granulomas, some degree of hepatic steatosis and focal necrosis. Mice fed normal-chow did not present productive granulomas and hepatic steatosis. The morphometric evaluation of hepatic granulomas did not reach statistical significance (p > 0.05) between diets assayed. The high-fat diet for long-term produces effects on schistosomiasis mansoni outcome.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 115, Issue 4, April 2007, Pages 324-332
Journal: Experimental Parasitology - Volume 115, Issue 4, April 2007, Pages 324-332
نویسندگان
Renata Heisler Neves, Alba Cristina Miranda de Barros Alencar, Michele Costa-Silva, Márcia Barbosa Águila, Carlos Alberto Mandarim-de-Lacerda, José Roberto Machado-Silva, Delir Corrêa Gomes,