کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371759 1302539 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Roxithromycin potentiates the effects of chloroquine and mefloquine on multidrug-resistant Plasmodium falciparum in vitro
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Roxithromycin potentiates the effects of chloroquine and mefloquine on multidrug-resistant Plasmodium falciparum in vitro
چکیده انگلیسی

Chloroquine (CQ) and mefloquine (MQ) are no longer potent antimalarial drugs due to the emergence of resistant Plasmodium falciparum. Combination therapy has become the standard for many regimes in overcoming drug resistance. Roxithromycin (ROM), a known p-glycoprotein inhibitor, is reported to have antimalarial activity and it is hoped it will potentiate the effects of both CQ/MQ and reverse CQ/MQ-resistance. We assayed the effects of CQ and MQ individually and in combination with ROM on synchronized P. falciparum (Dd2 strain) cultures. The IC50 values of CQ and MQ were 60.0 ± 5.0 and 16.0 ± 3.0 ng/ml; these were decreased substantially when combined with ROM. Isobolograms indicate that CQ–ROM combinations were relatively more synergistic (mean FICI 0.70) than MQ–ROM (mean FICI 0.85) with their synergistic effect at par with CQ–verapamil (VRP) (mean FICI 0.64) and MQ–VRP (mean FICI 0.60) combinations. We conclude that ROM potentiates the CQ/MQ response on multidrug-resistant P. falciparum.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 115, Issue 4, April 2007, Pages 387–392
نویسندگان
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