کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4371975 1302554 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A cathepsin L-like protease from Strongylusvulgaris: An orthologue of Caenorhabditiselegans CPL-1
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
A cathepsin L-like protease from Strongylusvulgaris: An orthologue of Caenorhabditiselegans CPL-1
چکیده انگلیسی

Cathespin L-like proteases (CPLs), characterized from a wide range of helminths, are significant in helminth biology. For example, in Caenorhabditiselegans CPL is essential for embryogenesis. Here, we report a cathepsin L-like gene from three species of strongyles that parasitize the horse, and describe the isolation of a cpl gene (Sv-cpl-1) from Strongylusvulgaris, the first such from equine strongyles. It encodes a protein of 354 amino acids with high similarity to other parasitic Strongylida (90–91%), and C.elegans CPL-1 (87%), a member of the same Clade. As S.vulgariscpl-1 rescued the embryonic lethal phenotype of the C.eleganscpl-1 mutant, these genes may be orthologues, sharing the same function in each species. Targeting Sv-CPL-1 might enable novel control strategies by decreasing parasite development and transmission.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 121, Issue 4, April 2009, Pages 293–299
نویسندگان
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