کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4372147 1302569 2008 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasmodium chabaudi: Efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Plasmodium chabaudi: Efficacy of artemisinin + curcumin combination treatment on a clone selected for artemisinin resistance in mice
چکیده انگلیسی

Recent studies have proposed curcumin as a potential partner for artemisinin in artemisinin combination therapies to treat malaria infections. The efficacy of curcumin alone and in combination with artemisinin was evaluated on a clone of Plasmodium chabaudi selected for artemisinin resistance in vivo. The addition of piperine as an enhancer of curcumin activity was also tested.Results indicated that curcumin, both alone and in combination with piperine had only a modest antimalarial effect and was not able to reverse the artemisinin-resistant phenotype or significantly affect growth of the tested clone when used in combination with artemisinin. This is in contrast with previous in vivo work and calls for further experimental evaluation of the antimalarial potential of curcumin.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 119, Issue 2, June 2008, Pages 304–307
نویسندگان
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