کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4372200 1302579 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasmodium berghei: Development of an irreversible experimental malaria model in Wistar rats
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
پیش نمایش صفحه اول مقاله
Plasmodium berghei: Development of an irreversible experimental malaria model in Wistar rats
چکیده انگلیسی

A protocol to infect five-week-old Wistar rats by Plasmodium berghei which resulted in 100% mortality was developed in this work. In order to accomplish this goal, the effect of the administration of 107 and 108 parasitized erythrocytes by i.v. and i.p. route was investigated. The animals inoculated with 107 parasitized red blood cells by i.p. and i.v. routes showed 25 and 50% mortality, respectively. Inoculation with 108 parasitized erythrocytes by both routes resulted in a 100% lethal infection. The i.v. inoculation showed less scattered results and it was preferred over the i.p. route. The suitability of the protocol developed was evaluated by treating infected Wistar rats with chloroquine (30 mg/kg/day). A decreased parasitemia after the treatment was observed until the complete eradication of the parasite, around 10 days post-inoculation. Parasitemia depression after chloroquine treatment demonstrates the utility of the model developed to test new antimalarial drugs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Parasitology - Volume 113, Issue 3, July 2006, Pages 193–196
نویسندگان
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