Amperometric Sensor for Tetracycline Determination Based on Molecularly Imprinted Technique

Tetracycline (TC), a widely used broad spectrum antibiotic, is excreted to environment seriously. Because of its harmful effects, it is essential to establish an effective method for TC determintation. In this work, we fabricated an electrochemical sensor for TC detection based on molecularly imprinted technique. The molecularly imprinted polymer was thermalpolymerized on Ti substrate electrodeposited with micro-nano Pt cluster (MIP-Pt/Ti). The linear range was in a TC concentration range from 0.1 to 10 mg L-1, and the detection limit was 0.026 mg L-1 (S/N = 3). The current change of TC on MIP-Pt/Ti electrode was 10 and 14 times than that of CTC and CAP, respectively. The results indicated that this electrochemical sensor exhibited good sensitivity and selectivity for TC.