Caffeic Acid Phenethyl Ester Protect Mice Hepatic Damage Against Cadmium Exposure

The aim of this study is to approach the possible effect and mechanism of caffeic acid phenethyl ester (CAPE) against the toxicity of Cadmium(Cd) on mice liver.MethodsIn vivo assays have been performed by evaluating the oxidative damage marker and the antioxidant parameters, meanwhile, the histopathological changes were also observed.ResultsIt was revealed that the intoxication of Cd could increase the concentration of oxidative damage and decrease the content of antioxidant system, the impact of Cd on liver damage can be suppressed by the effect of CAPE by lowering the oxidative damage levels and improving the activities of antioxidant enzymes.ConclusionFrom the data obtained from the studies, we found that the protection effect of CAPE on Cd toxicity was not solely dependent on the antioxidant effect, however, the evidence of CAPE playing a role in the amelioration of Cd toxicity probably showed that CAPE can be a promising agent in the treatment of Cd exposure.