کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4419745 1618948 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ecotoxicity and genotoxicity of a binary combination of triclosan and carbendazim to Daphnia magna
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Ecotoxicity and genotoxicity of a binary combination of triclosan and carbendazim to Daphnia magna
چکیده انگلیسی


• Daphnia magna showed to be more sensitive to carbendazim than to triclosan.
• DNA damages occurred in daphnids cells exposed to carbendazim and triclosan.
• Carbendazim ecological relevant exposures (NOECreprod=5 μg/L) induced DNA damage.
• Synergism (DNA damage) was observed in mixtures and mainly induced by triclosan.

In the environment, chemical substances appear as complex mixtures and consequently organisms are exposed to a variety of chemicals from different sources (e.g. wastewater treatment plants, agriculture runoffs). When studying chemical mixtures, there are two conceptual models usually used to predict toxicity: the Independent Action (IA) and Concentration Addition (CA) models. However, deviations from these reference models can occur as synergism or antagonism, dose ratio or dose level dependency. The aim of the present study was to investigate the effects of triclosan and carbendazim, and their binary mixture to Daphnia magna. With this purpose, immobilisation, feeding inhibition, and reproduction were assessed as main ecotoxicity endpoints. In addition, in vivo genotoxicity of both chemicals was investigated using the comet assay. In the single exposure, carbendazim was more toxic to D. magna than triclosan. When daphnids were exposed to both single compounds, DNA damage was observed. Concerning mixture exposures, different endpoints followed different patterns of response, from additivity: IA model (feeding inhibition and reproduction data), to deviations that indicate interaction between chemicals inside the organism: dose level dependency (immobilisation data) and dose ratio dependency (DNA damage). This study showed that additivity does not rule the dose–effect relation in chemical mixtures of carbendazim and triclosan and interactions between both chemicals might induce generally higher toxicity than predicted based on single chemical exposures.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 115, May 2015, Pages 279–290
نویسندگان
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