کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4420809 1618978 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for metabolic imbalance of vitamin A2 in wild fish chronically exposed to metals
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Evidence for metabolic imbalance of vitamin A2 in wild fish chronically exposed to metals
چکیده انگلیسی

In a recent study on indigenous yellow perch chronically exposed to metals, we reported a negative correlation between liver metal concentration and liver transcription levels of genes encoding for enzymes involved in the metabolism of retinoids. We therefore speculated that metals, and especially the non-essential metal Cd, could alter the metabolism of retinoids in wild fish. Thus the present field study investigates the impact of in situ metal exposure on retinoid storage. A total of 55 yellow perch (Perca flavescens) were sampled in six lakes representing a metal contamination gradient (8≤N≤10 per lake). Our results show that yellow perch from Cd-contaminated lakes had significantly higher concentrations of liver dehydroretinol and dehydroretinyl esters than did fish from reference lakes. However, the increase in retinyl ester stores with increasing Cd concentrations was quantitatively much more important than the increase in free dehydroretinol. As a result, a significant decrease in the percentage of hepatic free dehydroretinol with increasing renal Cd concentrations was observed. These results suggest that the enzymes and the binding proteins involved in vitamin A homeostasis are inhibited by the presence of Cd. Alternatively, the increase in tissue vitamin A (antioxidant) levels could serve to better counteract the oxidative stress engendered by Cd exposure. Overall our findings illustrate that vitamin A2 homeostasis can be altered as a consequence of chronic exposure to low Cd concentrations. Thus, in the context of environmental risk assessment, the percentage of liver free dehydroretinol can be considered as a biomarker of for in situ Cd exposure.


► Yellow perch living in contaminated lakes display high liver vitamin A2 levels.
► Indirect effects of Cd on fish prey do not contribute to higher level of vitamin A2.
► The proportion of free dehydroretinol decreases with increasing kidney Cd level.
► The percentage of free dehydroretinol could be used as a biomarker of Cd exposure

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 85, 1 November 2012, Pages 88–95
نویسندگان
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