کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4421045 1618988 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
First evidence for the presence of efflux pump in the earthworm Eisenia andrei
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
First evidence for the presence of efflux pump in the earthworm Eisenia andrei
چکیده انگلیسی

Efflux pumps are transport proteins involved in the extrusion of toxic substrates from cells to the external environment. Activities of efflux pumps have been found in many organisms, however such activity has not been evidenced in earthworms. Adult Eisenia andrei earthworms were exposed to efflux modulators – verapamil (a known inhibitor of efflux pump protein) and dexamethasone (a known inducer of efflux activity) – and the amount of absorbed fluorescent dye rhodamine B was measured. The results showed that verapamil inhibited efflux activity and decreased removal of rhodamine B, whereas dexamethasone induced efflux activity and increased removal of rhodamine B. This is the first evidence of the presence of efflux pump in earthworm Eisenia andrei. Since earthworms are often used as test organisms due to their sensitive reactions towards environmental influences, the discovery of efflux pump activity can contribute to the better understanding of toxicity of certain pollutants.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ecotoxicology and Environmental Safety - Volume 75, 1 January 2012, Pages 40–45
نویسندگان
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