Toxicity reference values for mink exposed to 2,3,7,8-tetrachlodibenzo-p-dioxin (TCDD) equivalents (TEQs)

Dietary and tissue residue-based toxicity reference values (TRVs) were derived for mink from the published results of studies in which mink were exposed to polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), or related compounds. Because the primary mechanism of toxic action at the least concentration for these compounds is related to activation of the aryl hydrocarbon receptor (AhR), TRVs were described on the basis of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) equivalents (TEQ). Each published study was critically reviewed for its usefulness in deriving a TRV based on the following criteria: (1) close relatedness of the test species to the wildlife receptor of concern (only mink studies were reviewed in this paper); (2) chronic duration of exposure which included sensitive life stages to evaluate potential developmental and reproductive effects; (3) measurement of ecologically relevant endpoints; (4) availability of congener-specific data to calculate TEQ concentrations; and (5) minimal impact of co-contaminants. Dietary TRVs for mink exposed to TEQ ranged from 12.1 to 56.6 ng TEQ/kg feed (wet weight) for the no observable adverse effect level (NOAEL) and from 50.4 to 242 ng TEQ/kg feed (wet weight) for the lowest observable adverse effect level (LOAEL). TRVs based on tissue residue concentrations ranged from 50.2 to 77.8 ng TEQ/kg liver (wet weight) for the no observable adverse effect concentration (NOAEC) and the value was 189 ng TEQ/kg liver (wet weight) for the lowest observable adverse effect concentration (LOAEC). Selection of a TRV should be based on studies of compounds that are most similar to those at a site of interest. In particular, it was determined that the effects of PCDFs could not be accurately predicted from the use of TEQ-based TRVs developed from studies of PCDDs or PCBs. Risk assessors should be aware that exceedance of these TRVs would not necessarily be expected to lead to ecologically relevant adverse effects because of the inherently conservative assumptions made in the TRV derivation process.