کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4424377 1619177 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dose-response relationship between polycyclic aromatic hydrocarbon metabolites and risk of diabetes in the general Chinese population
ترجمه فارسی عنوان
رابطه بین دوز پاسخ بین متابولیت های هیدروکربنی معطر چند حلقه ای و خطر ابتلا به دیابت در کل جمعیت چینی است
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
چکیده انگلیسی


• PAHs metabolites were dose-responsive related to increased risk of diabetes.
• The associations were more evident in relatively healthy subjects.
• The addition of some PAHs metabolites improved the discrimination of diabetes.

The incidence of diabetes is increasing rapidly in Chinese population, and it has been postulated that environmental factors may play a role in the etiology of diabetes. Therefore, we aimed to investigate the association between PAHs exposure and risk of diabetes in a community-based population of 2824 participants with completed questionnaires, measurements of biochemical indices, and urinary PAHs metabolites. We found that elevated urinary PAHs metabolites were associated, in a dose-dependent manner, with increased risk of diabetes. Particularly, these associations were more evident in subjects who were female, less than 55 years old, nonsmokers, and normal weight. In addition, there was a modest improvement in diabetes discrimination of prediction models when incorporating certain PAHs metabolites into conventional risk factors (CRF). Overall, our data suggested that there may be a dose-dependent relationship between PAHs metabolites and risk of diabetes among general Chinese population.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 195, December 2014, Pages 24–30
نویسندگان
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