کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4425104 1619211 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM1.0) and pollen allergens
چکیده انگلیسی

Asthma is currently defined as a chronic inflammatory disease of the airway. Several evidence indicate that vehicle emissions in cities is correlated with the allergic respiratory diseases.In the present study, we evaluated in the A549 cells the production and release of IL-4, IL-5 and IL-13 after treatment with sub-micron PM1.0 particles (PM1.0), Parietaria officinalis (ALL), and PM1.0 + ALL together.Our data demonstrated that PM1.0 + ALL together exhibited the greatest capacity to induce A549 cells to enhance the expression of IL-4 and IL-5 compared with the only PM1.0 or ALL treatment. Interestingly, IL-13 that is necessary for allergen-induced airway hyper responsiveness, is increased in cells treated with PM1.0 + ALL together, but is higher expressed when the cells are treated only with the allergen.Our data support the hypothesis that the urban environment damage the acinar lung units and activates cells of the immune system.


► The genetic factors plays a key role in the development of the asthma.
► Its development can only be made in the presence of specific environmental factors.
► We evaluated in the A549 cells the production and release of IL-4, IL-5 and IL-13.
► IL-4, IL-5 and IL-13 expression increased when the A549 cells are treated with PM1.0 + ALL together.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 161, February 2012, Pages 64–69
نویسندگان
, , , , , , , , ,