کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4425251 1309098 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An evaluation of the toxicity and bioaccumulation of cisplatin in the marine environment using the macroalga, Ulva lactuca
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
An evaluation of the toxicity and bioaccumulation of cisplatin in the marine environment using the macroalga, Ulva lactuca
چکیده انگلیسی

The cytotoxic drug, cisplatin (cis-PtCl2(NH3)2), has been added to cultures of the marine macroalga, Ulva lactuca, under various experimental conditions. Both accumulation and internalisation over a 48 h period was greater when cisplatin was added to coastal sea water (salinity = 33) from a distilled water solution than when added to either sea water or estuarine water (salinity = 16.5) from a saline solution. This effect is attributed to the greater abundance of the more reactive monoaqua complex (cis-PtCl(OH2)(NH3)2+) in the distilled water solution and kinetic constraints on its conversion back to cis-PtCl2(NH3)2 in sea water. Despite its mode of action at the cellular level, cisplatin added up to concentrations of 150 nM did not incur a measurable reduction in the efficiency of photochemical energy conversion under any of experimental conditions tested.


► This study is the first to examine the biogeochemistry and toxicity of a cytotoxic drug in the marine environment.
► Cisplatin is accumulated and internalised by the marine macroalga, Ulva lactuca.
► Accumulation is greater when the drug is administered from a distilled water solution than from a saline solution.
► Results are consistent with the greater abundance of the more reactive aquated complexes in pure water.
► Cisplatin is not phytotoxic to the alga over the concentration range (<150 nM) studied.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 159, Issue 12, December 2011, Pages 3504–3508
نویسندگان
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