کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4426127 1309120 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis
چکیده انگلیسی

The pharmaceutical diclofenac (DCF) is released in considerably high amounts to the aquatic environment. Photo-transformation of DCF was reported as the main degradation pathway in surface waters and was found to produce metabolites with enhanced toxicity to the green algae Scenedesmus vacuolatus. We identified and subsequently confirmed 2-[2-(chlorophenyl)amino]benzaldehyde (CPAB) as a transformation product with enhanced toxicity using effect-directed analysis. The EC50 of CPAB (4.8 mg/L) was a factor of 10 lower than that for DCF (48.1 mg/L), due to the higher hydrophobicity of CPAB (log Kow = 3.62) compared with DCF (log Dow = 2.04) at pH 7.0.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Pollution - Volume 158, Issue 5, May 2010, Pages 1461–1466
نویسندگان
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