Patient specific tumor growth prediction using multimodal images

• We present a tumor growth model integrating cell metabolism and mass effect.
• We present a tumor growth model directly associated with clinical CT and FDG-PET.
• We introduce Intracellular Volume Fraction (ICVF) into tumor modeling.
• We present the principle to calculate ICVF using dual-phase CT.

Personalized tumor growth model is valuable in tumor staging and therapy planning. In this paper, we present a patient specific tumor growth model based on longitudinal multimodal imaging data including dual-phase CT and FDG-PET. The proposed Reaction–Advection–Diffusion model is capable of integrating cancerous cell proliferation, infiltration, metabolic rate and extracellular matrix biomechanical response. To bridge the model with multimodal imaging data, we introduce Intracellular Volume Fraction (ICVF) measured from dual-phase CT and Standardized Uptake Value (SUV) measured from FDG-PET into the model. The patient specific model parameters are estimated by fitting the model to the observation, which leads to an inverse problem formalized as a coupled Partial Differential Equations (PDE)-constrained optimization problem. The optimality system is derived and solved by the Finite Difference Method. The model was evaluated by comparing the predicted tumors with the observed tumors in terms of average surface distance (ASD), root mean square difference (RMSD) of the ICVF map, average ICVF difference (AICVFD) of tumor surface and tumor relative volume difference (RVD) on six patients with pathologically confirmed pancreatic neuroendocrine tumors. The ASD between the predicted tumor and the reference tumor was 2.4 ± 0.5 mm, the RMSD was 4.3 ± 0.4%, the AICVFD was 2.6 ± 0.6%, and the RVD was 7.7 ± 1.3%.

The following figure shows the predicted tumor growth and the comparison between the prediction and the reference (the 2nd follow-up) of two patients regarding Intracellular Volume Fraction (ICVF) map, isocontour and ICVF on the tumor surface.Figure optionsDownload high-quality image (258 K)Download as PowerPoint slide