کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
444118 692887 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation
موضوعات مرتبط
مهندسی و علوم پایه مهندسی کامپیوتر گرافیک کامپیوتری و طراحی به کمک کامپیوتر
پیش نمایش صفحه اول مقاله
Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation
چکیده انگلیسی

The main function of the respiratory system is gas exchange. Since many disease or injury conditions can cause biomechanical or material property changes that can alter lung function, there is a great interest in measuring regional lung ventilation and regional specific volume change. We describe a registration-based technique for estimating local lung expansion from multiple respiratory-gated CT images of the thorax. The degree of regional lung expansion is measured using the Jacobian (a function of local partial derivatives) of the registration displacement field, which we show is directly related to specific volume change. We compare the ventral–dorsal patterns of lung expansion estimated across five pressure changes to a xenon CT based measure of specific ventilation in five anesthetized sheep studied in the supine orientation. Using 3D image registration to match images acquired at 10 cm H2OH2O and 15 cm H2OH2O airway pressures gave the best match between the average Jacobian and the xenon CT specific ventilation (linear regression, average r2=0.73r2=0.73).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Image Analysis - Volume 12, Issue 6, December 2008, Pages 752–763
نویسندگان
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