کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
444465 692986 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structural determinants of the alpha2 adrenoceptor subtype selectivity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Structural determinants of the alpha2 adrenoceptor subtype selectivity
چکیده انگلیسی

Alpha2-adrenergic receptor (α2-AR) subtypes, acting mainly on the central nervous and cardiovascular systems, represent important targets for drug design, confirmed by the high number of studies published so far. Presently, only a few α2-AR subtype selective compounds are known. Using homology modeling and ligand docking, the present study analyzes the similarities and differences between binding sites, and between extracellular loops of the three subtypes of α2-ARs. Several α2-AR subtype selective ligands were docked into the active sites of the three α2-AR subtypes, key interactions between ligands and receptors were mapped, and the predicted results were compared with the available experimental data. Binding site analysis reveals a strong identity between important amino acid residues in each receptor, the very few differences being the key toward modulating selectivity of α2-AR ligands. The observed differences between binding site residues provide an excellent starting point for virtual screening of chemical databases, in order to identify potentially selective ligands for α2-ARs.

Figure optionsDownload high-quality image (157 K)Download as PowerPoint slideHighlights
► The sequence homology exhibited by α2-ARs is extremely high (over 80%).
► Only few α2-ARs subtype-selective compounds have been reported.
► Docking and binding site analysis revealed several residues important for designing new selective ligands.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Graphics and Modelling - Volume 29, Issue 8, August 2011, Pages 1030–1038
نویسندگان
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