کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4469725 1622568 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exposure to traffic pollution, acute inflammation and autonomic response in a panel of car commuters
ترجمه فارسی عنوان
قرار گرفتن در معرض آلودگی ترافیکی، التهاب حاد و پاسخ اتوایی در یک گروه از مسافران ماشین
کلمات کلیدی
رفت و آمد اتومبیل، اکسید نیتریک اکسید شده، تنش قلبی، آسم
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• We investigated in-vehicle exposures and acute response among daily car commuters.
• Elevated exhaled nitric oxide and breath malondialdehyde following 2 h commute.
• Decreased heart rate variability observed following 2 h commute.
• In-vehicle water soluble organic carbon most predictive of response.

BackgroundExposure to traffic pollution has been linked to numerous adverse health endpoints. Despite this, limited data examining traffic exposures during realistic commutes and acute response exists.ObjectivesWe conducted the Atlanta Commuters Exposures (ACE-1) Study, an extensive panel-based exposure and health study, to measure chemically-resolved in-vehicle exposures and corresponding changes in acute oxidative stress, lipid peroxidation, pulmonary and systemic inflammation and autonomic response.MethodsWe recruited 42 adults (21 with and 21 without asthma) to conduct two 2-h scripted highway commutes during morning rush hour in the metropolitan Atlanta area. A suite of in-vehicle particulate components were measured in the subjects’ private vehicles. Biomarker measurements were conducted before, during, and immediately after the commutes and in 3 hourly intervals after commutes.ResultsAt measurement time points within 3 h after the commute, we observed mild to pronounced elevations relative to baseline in exhaled nitric oxide, C-reactive-protein, and exhaled malondialdehyde, indicative of pulmonary and systemic inflammation and oxidative stress initiation, as well as decreases relative to baseline levels in the time-domain heart-rate variability parameters, SDNN and rMSSD, indicative of autonomic dysfunction. We did not observe any detectable changes in lung function measurements (FEV1, FVC), the frequency-domain heart-rate variability parameter or other systemic biomarkers of vascular injury. Water soluble organic carbon was associated with changes in eNO at all post-commute time-points (p<0.0001).ConclusionsOur results point to measureable changes in pulmonary and autonomic biomarkers following a scripted 2-h highway commute.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 133, August 2014, Pages 66–76
نویسندگان
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