Lead exposure and rate of change in cognitive function in older women

• Evidence of an association between lead and cognitive decline in women is lacking.
• Higher long-term lead exposure predicted faster decline on some cognitive tests.
• Associations were weak, perhaps due to low lead exposures in these women.

BackgroundHigher long-term cumulative lead exposure predicts faster cognitive decline in older men, but evidence of an association in women is lacking.ObjectiveTo determine if there is an association between lead exposure and cognitive decline in women.MethodsThis study considers a sample of 584 women from the Nurses' Health Study who live in or near Boston, Massachusetts. We quantified lead exposure using biomarkers of lead exposure assessed in 1993–2004 and evaluated cognitive decline by repeated performance on a telephone battery of cognitive tests primarily assessing learning, memory, executive function, and attention completed in 1995–2008. All cognitive test scores were z-transformed for use in analyses. We used linear mixed models with random effects to quantify the association between each lead biomarker and change in cognition overall and on each individual test.ResultsConsideration of individual tests showed greater cognitive decline with increased tibia lead concentrations, a measure of long-term cumulative exposure, for story memory and category fluency. The estimated excess annual decline in overall cognitive test z-score per SD increase in tibia bone lead concentration was suggestive, although the confidence intervals included the null (0.024 standard units, 95% confidence interval: −0.053, 0.004 – an additional decline in function equivalent to being 0.33 years older). We found little support for associations between cognitive decline and patella or blood lead, which provide integrated measures of exposure over shorter timeframes.ConclusionsLong-term cumulative lead exposure may be weakly associated with faster cognitive decline in community-dwelling women, at least in some cognitive domains.