کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4469883 1622579 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Urinary concentrations of bisphenol A in an urban minority birth cohort in New York City, prenatal through age 7 years
چکیده انگلیسی

BackgroundDespite growing concern over potential health effects associated with exposures to the endocrine disruptor, bisphenol A (BPA), insufficient information is available on determinants of BPA concentrations among minority populations in the US.ObjectivesTo describe concentrations and predictors of BPA in an inner-city longitudinal birth cohort.MethodsWe analyzed spot urines for total BPA collected during pregnancy and child ages 3, 5, and 7 years from African Americans and Dominicans (n=568) enrolled in the Columbia Center for Children's Environmental Health birth cohort and residing in Northern Manhattan and the South Bronx. Adjusting for specific gravity, generalized estimating equations were used to compare BPA concentrations across paired samples and linear regression analyses were used to determine relationships between BPA, season of sample collection, socio-demographic variables and urinary concentrations of phthalate metabolites.ResultsBPA was detected in ≥94% of samples. Prenatal concentrations were significantly lower than postnatal concentrations. Geometric means were higher among African Americans compared to Dominicans in prenatal (p=0.008), 5 year (p<0.001) and 7 year (p=0.017) samples. Geometric means at 5 and 7 years were higher (p=0.021, p=0.041 respectively) for children of mothers never married compared to mothers ever married at enrollment. BPA concentrations were correlated with phthalate metabolite concentrations at prenatal, 3, 5 and 7 years (p-values <0.05). Postnatal BPA concentrations were higher in samples collected during the summer.ConclusionsThis study shows widespread BPA exposure in an inner-city minority population. BPA concentration variations were associated with socio-demographic characteristics and other xenobiotics.


► A cohort of minority mothers and children in NYC had pervasive exposure to BPA.
► Children had significantly higher concentrations than their mothers during pregnancy.
► African Americans had significantly higher concentrations than Dominicans.
► Children's BPA concentrations were higher in samples collected during the summer.
► BPA and phthalate metabolite concentrations were significantly correlated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 122, April 2013, Pages 38–44
نویسندگان
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