کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4469991 | 1622583 | 2012 | 6 صفحه PDF | دانلود رایگان |

BackgroundFew studies have examined the acute cardiorespiratory effects of specific volatile organic compound (VOC) exposures from traffic pollution.MethodsA cross-over study was conducted among 42 healthy adults during summer 2010 in Ottawa, Canada. Participants cycled for 1-h along high and low-traffic routes and VOC exposures were determined along each route. Lung function, exhaled nitric oxide, and heart rate variability were monitored before cycling and 1–4 h after the start of cycling. Bayesian hierarchical models were used to examine the relationship between 26 VOCs and acute changes in clinical outcomes adjusted for potential confounding factors.ResultsEach inter-quartile range (IQR) increase in propane/butane exposure was associated with a 2.0 millisecond (ms) (95% CI: 0.65, 3.2) increase in SDNN (standard deviation of normal-to-normal intervals), a 24 ms2 (95% CI: 6.6, 41) increase in HF (high frequency power), and a 65 ms2 (95% CI: 11, 118) increase in LF (low frequency power) in the hours following cycling. IQR increases in ethane and isoprene were associated with a 5.8 ms (95% CI: −9.8, −1.7): decrease in SDNN and a 24 ms2 (95% CI: −44, −7.9) decrease in HF, respectively. IQR increases in benzene exposure were associated with a 1.7 ppb (95% CI: 1.1, 2.3) increase in exhaled nitric oxide and each IQR increase in 3-methylhexane exposure was associated with a 102 mL (95% CI: −157, −47) decrease in forced expiratory volume in 1-s.ConclusionsExposure to traffic-related VOCs may contribute to acute changes in lung function, inflammation, or heart rate variability.
► The acute cardiorespiratory effects of VOC exposures were examined among cyclists.
► Outcomes included heart rate variability, lung function, and exhaled NO.
► Most VOCs were not associated with cardiorespiratory outcomes.
► Heterogeneous associations were observed for a small number of VOCs.
► Future studies should replicate these findings.
Journal: Environmental Research - Volume 118, October 2012, Pages 118–123