Iron deficiency is associated with increased levels of blood cadmium in the Korean general population: Analysis of 2008–2009 Korean National Health and Nutrition Examination Survey data

IntroductionWe present data from the Korean National Health and Nutrition Examination Survey 2008–2009 on the distribution of blood cadmium levels and their association with iron deficiency in a representative sample of the adult Korean population.MethodsSerum ferritin was categorized into three levels: low (serum ferritin <15.0 μg/L), low normal (15.0–30.0 μg/L for women and 15.0–50.0 for men), and normal (≥30.0 μg/L for women and ≥50.0 for men), and its association with blood cadmium level was assessed after adjustment for various demographic and lifestyle factors.ResultsGeometric means of blood cadmium in the low serum ferritin group in women, men, and all participants were significantly higher than in the normal group. Additionally, multiple regression analysis after adjusting for various covariates showed that blood cadmium was significantly higher in the low-ferritin group in women, men, and all participants compared with the normal group. We also found an association between serum ferritin and blood cadmium among never-smoking participants.DiscussionWe found, similar to other recent population-based studies, an association between iron deficiency and increased blood cadmium in men and women, independent of smoking status. The results of the present study show that iron deficiency is associated with increased levels of blood cadmium in the general population.

► We showed the association of blood cadmium levels with iron deficiency in a representative sample of the adult Korean population.
► This study was based on data obtained by Korean National Health and Nutrition Examination Survey 2008–2009.
► The present study showed this association in men and in women.