کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4470196 1314397 2011 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A combined approach to investigate the toxicity of an industrial landfill’s leachate: Chemical analyses, risk assessment and in vitro assays
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
A combined approach to investigate the toxicity of an industrial landfill’s leachate: Chemical analyses, risk assessment and in vitro assays
چکیده انگلیسی

Solid wastes constitute an important and emerging problem. Landfills are still one of the most common ways to manage waste disposal. The risk assessment of pollutants from landfills is becoming a major environmental issue in Europe, due to the large number of sites and to the importance of groundwater protection. Furthermore, there is lack of knowledge for the environmental, ecotoxicological and toxicological characteristics of most contaminants contained into landfill leacheates. Understanding leachate composition and creating an integrated strategy for risk assessment are currently needed to correctly face the landfill issues and to make projections on the long-term impacts of a landfill, with particular attention to the estimation of possible adverse effects on human health and ecosystem. In the present study, we propose an integrated strategy to evaluate the toxicity of the leachate using chemical analyses, risk assessment guidelines and in vitro assays using the hepatoma HepG2 cells as a model. The approach was applied on a real case study: an industrial waste landfill in northern Italy for which data on the presence of leachate contaminants are available from the last 11 years. Results from our ecological risk models suggest important toxic effects on freshwater fish and small rodents, mainly due to ammonia and inorganic constituents. Our results from in vitro data show an inhibition of cell proliferation by leachate at low doses and cytotoxic effect at high doses after 48 h of exposure.

Research highlights
► We study the toxicity of leachate from a non-hazardous industrial waste landfill.
► We perform chemical analyses, risk assessments and in vitro assays on HepG2 cells.
► Risk models suggest toxic effects due to ammonia and inorganic constituents.
► In vitro assays show that leachate inhibits cell proliferation at low doses.
► Leachate can induce cytotoxic effects on HepG2 cells at high doses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 111, Issue 4, May 2011, Pages 603–613
نویسندگان
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