کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4470216 1314398 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Serum PBDEs and age at menarche in adolescent girls: Analysis of the National Health and Nutrition Examination Survey 2003–2004
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Serum PBDEs and age at menarche in adolescent girls: Analysis of the National Health and Nutrition Examination Survey 2003–2004
چکیده انگلیسی

BackgroundPolybrominated diphenyl ethers (PBDEs), widely used as flame retardants since the 1970s, have exhibited endocrine disruption in experimental studies. Tetra- to hexa-BDE congeners are estrogenic, while hepta-BDE and 6-OH-BDE-47 are antiestrogenic. Most PBDEs also have antiandrogenic activity. It is not clear, however, whether PBDEs affect human reproduction.ObjectivesThe analysis was designed to investigate the potential endocrine disruption of PBDEs on the age at menarche in adolescent girls.MethodsWe analyzed the data from a sample of 271 adolescent girls (age 12–19 years) in the National Health and Nutrition Examination Survey (NHANES), 2003–2004. We estimated the associations between individual and total serum BDEs (BDE-28, -47, -99, -100, -153, and -154, lipid adjusted) and mean age at menarche. We also calculated the risk ratios (RRs) and 95% confidence intervals (CI) for menarche prior to age 12 years in relation to PBDE exposure.ResultsThe median total serum BDE concentration was 44.7 ng/g lipid. Higher serum PBDE concentrations were associated with slightly earlier ages at menarche. Each natural log unit of total BDEs was related to a change of −0.10 (95% CI: −0.33, 0.13) years of age at menarche and a RR of 1.60 (95% CI: 1.12, 2.28) for experiencing menarche before 12 years of age, after adjustment for potential confounders.ConclusionThese data suggest high concentrations of serum PBDEs during adolescence are associated with a younger age of menarche.


► Higher serum PBDE concentrations were associated with earlier age at menarche in adolescent girls.
► Serum PBDE concentrations were similar from 12 to 19 years in female adolescents in a cross-sectional survey.
► PBDE congeners were highly correlated and congener-specific associations remain to be studied.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 111, Issue 6, August 2011, Pages 831–837
نویسندگان
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