Statistical mechanics of neocortical interactions: Large-scale EEG influences on molecular processes

• Ca2+ waves and regional vector potentials interact via canonical momenta (p+qA).
• Canonical momenta (p+qA) influences are calculated at classical and quantum scales.
• New EEG data is fit to columnar-averaged models, overcoming previous data with severe outliers.
• Reviews of multiple steps of theory required to logically develop model of EEG data across multiple scales.
• Reviews of extended quantum coherence influence importance of quantum (p+qA).

Calculations further support the premise that large-scale synchronous firings of neurons may affect molecular processes. The context is scalp electroencephalography (EEG) during short-term memory (STM) tasks. The mechanism considered is Π=p+qAΠ=p+qA (SI units) coupling, where pp is the momenta of free Ca2+Ca2+ waves, q   the charge of Ca2+Ca2+ in units of the electron charge, and AA the magnetic vector potential of current II from neuronal minicolumnar firings considered as wires, giving rise to EEG. Data has processed using multiple graphs to identify sections of data to which spline-Laplacian transformations are applied, to fit the statistical mechanics of neocortical interactions (SMNI) model to EEG data, sensitive to synaptic interactions subject to modification by Ca2+Ca2+ waves.