کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496181 1623856 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model
چکیده انگلیسی


• We propose a model of intracellular signaling related to monosomy and trisomy of chromosome 6q.
• The model is calibrated based on the gene expression microarray data for the two types of medulloblastoma.
• Model simulations indicate the importance of SGK1 gene in the development of medulloblastoma.
• The model suggests a strong correlation between the cMyc protein level data and cancer prognosis.

Deregulation of signaling pathways and subsequent abnormal interactions of downstream genes very often results in carcinogenesis. In this paper, we propose a two-compartment model describing intricate dynamics of the target genes of the Wnt signaling pathway in medulloblastoma. The system of nine nonlinear ordinary differential equations accounts for the formation and dissociation of complexes as well as for the transcription, translation and transport between the cytoplasm and the nucleus. We focus on the interplay between MYC and SGK1 (serum and glucocorticoid-inducible kinase 1), which are the products of Wnt/β-catenin signaling pathway, and GSK3β (glycogen synthase kinase). Numerical simulations of the model solutions yield a better understanding of the process and indicate the importance of the SGK1 gene in the development of medulloblastoma, which has been confirmed in our recent experiments. The model is calibrated based on the gene expression microarray data for two types of medulloblastoma, characterized by monosomy and trisomy of chromosome 6q to highlight the difference between diagnoses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 354, 7 August 2014, Pages 105–112
نویسندگان
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