کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496189 1623869 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evolutionary dynamics of the Warburg effect: Glycolysis as a collective action problem among cancer cells
ترجمه فارسی عنوان
دینامیک تکاملی اثر واربورگ: گلیکولیز به عنوان یک مشکل مشترک در میان سلول های سرطانی
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
چکیده انگلیسی


• The upregulation of glycolysis in tumors is common even when oxygen is not limiting.
• The adaptive value of this “Warburg effect” is unclear.
• Glycolysis is costly for a cell but the ensuing acidity is beneficial for the tumor.
• A collective action problem among cancer cells arises.
• Game theory shows that the acidity induced by glycolysis can explain the Warburg effect.

The upregulation of glycolysis in cancer cells (the “Warburg effect”) is common and has implications for prognosis and treatment. As it is energetically inefficient under adequate oxygen supply, its adaptive value for a tumor remains unclear. It has been suggested that the acidity produced by glycolysis is beneficial for cancer cells because it promotes proliferation against normal cells. Current models of this acid-mediated tumor invasion hypothesis, however, do not account for increased glycolysis under non-limiting oxygen concentrations and therefore do not fully explain the Warburg effect. Here I show that the Warburg effect can be explained as a form of cooperation among cancer cells, in which the products of glycolysis act as a public good, even when oxygen supply is high enough to make glycolysis energetically inefficient. A multiplayer game with non-linear, non-monotonic payoff functions that models the benefits of the acidity induced by glycolysis reveals that clonal selection can stabilize glycolysis even when energetically costly, that is, under non-limiting oxygen concentration. Characterizing the evolutionary dynamics of glycolysis reveals cases in which anti-cancer therapies that rely on the modification of acidity can be effective.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 341, 21 January 2014, Pages 1–8
نویسندگان
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