کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496209 1623868 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A mathematical model of the initial interaction between Mycobacterium tuberculosis and macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
A mathematical model of the initial interaction between Mycobacterium tuberculosis and macrophages
چکیده انگلیسی


• Local optima exist in the early race between Mycobacterium tuberculosis and host cells.
• Distribution of host/pathogen in parameter space determines disease survival.
• Oscillations in bacterial numbers could contribute to variable incubation periods.

There is a large body of literature describing molecular level interactions between Mycobacterium tuberculosis (Mtb) and macrophages. Macrophages initiate a range of anti-bacterial mechanisms in response to infection, and Mtb is capable of surviving and circumventing many of these responses. We apply a computational approach to ask: what are the effects on the cellular level of these opposing interactions? The model considers the interplay between bacterial killing and the pathogen's interference with macrophage function. The results reveal an oscillating balance between host and pathogen, but the balance is transient and varies in length, indicating that stochasticity in the bacterial population or host response could contribute to the diverse incubation periods observed in exposed individuals. The model captures host and strain variation and gives new insight into host-pathogen compatibility and co-evolution.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 342, 7 February 2014, Pages 23–32
نویسندگان
, ,