کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496363 1623880 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The influence of assortativity on the robustness and evolvability of gene regulatory networks upon gene birth
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
The influence of assortativity on the robustness and evolvability of gene regulatory networks upon gene birth
چکیده انگلیسی


• We study how topology affects the robustness and evolvability of GRNs.
• We examine the effects of varying assortativity in models of GRNs.
• As assortativity increases, robustness increases and evolvability decreases.
• Increased assortativity reduces attractor sizes, which leads to higher robustness.
• Increased assortativity reduces out-component sizes, which causes lower evolvability.

Gene regulatory networks (GRNs) represent the interactions between genes and gene products, which drive the gene expression patterns that produce cellular phenotypes. GRNs display a number of characteristics that are beneficial for the development and evolution of organisms. For example, they are often robust to genetic perturbation, such as mutations in regulatory regions or loss of gene function. Simultaneously, GRNs are often evolvable as these genetic perturbations are occasionally exploited to innovate novel regulatory programs. Several topological properties, such as degree distribution, are known to influence the robustness and evolvability of GRNs. Assortativity, which measures the propensity of nodes of similar connectivity to connect to one another, is a separate topological property that has recently been shown to influence the robustness of GRNs to point mutations in cis-regulatory regions. However, it remains to be seen how assortativity may influence the robustness and evolvability of GRNs to other forms of genetic perturbation, such as gene birth via duplication or de novo origination. Here, we employ a computational model of genetic regulation to investigate whether the assortativity of a GRN influences its robustness and evolvability upon gene birth. We find that the robustness of a GRN generally increases with increasing assortativity, while its evolvability generally decreases. However, the rate of change in robustness outpaces that of evolvability, resulting in an increased proportion of assortative GRNs that are simultaneously robust and evolvable. By providing a mechanistic explanation for these observations, this work extends our understanding of how the assortativity of a GRN influences its robustness and evolvability upon gene birth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 330, 7 August 2013, Pages 26–36
نویسندگان
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