A rational quantitative approach to determine the best dosing regimen for a target therapeutic effect: A unified formalism for antibiotic evaluation

► We developed a mathematical approach to evaluate the efficacy of antibiotic agents. ► A unified pharmacokinetics/pharmacodynamics formalism for a whole antibiotics range. ► Association of the in vivo drug concentration with the in vitro drug effect. ► An introduction of the Hill-dependency concept for antibiotic classification. ► Reveal surprising drug performance for different regimens.