Mechanical buckling of arterioles in collateral development

► We modeled arteriole buckling behavior associated with growth and remodeling. ► Arteriole length growth decreases the buckling pressure and buckling wavelength. ► Radius growth decreases the buckling pressure but increases buckling wavelength. ► Increasing wall thickness increases the buckling pressure and buckling wavelength. ► Adaptive growth makes arterioles prone to buckling & leads to tortuous collaterals.