کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4496656 | 1623902 | 2012 | 6 صفحه PDF | دانلود رایگان |

The subcellular localization of proteins is closely related to their functions. In this work, we propose a novel approach based on localization motifs to improve the accuracy of predicting subcellular localization of Gram-positive bacterial proteins. Our approach performed well on a five-fold cross validation with an overall success rate of 89.5%. Besides, the overall success rate of an independent testing dataset was 97.7%. Moreover, our approach was tested using a new experimentally-determined set of Gram-positive bacteria proteins and achieved an overall success rate of 96.3%.
► We introduce a novel approach based on localization motifs to improve the predicting accuracy.
► We introduce a novel position-specific frequency encoding approach.
► Our approach greatly improved the accuracy of prediction.
Journal: Journal of Theoretical Biology - Volume 308, 7 September 2012, Pages 135–140