کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496656 1623902 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Predicting Gram-positive bacterial protein subcellular localization based on localization motifs
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Predicting Gram-positive bacterial protein subcellular localization based on localization motifs
چکیده انگلیسی

The subcellular localization of proteins is closely related to their functions. In this work, we propose a novel approach based on localization motifs to improve the accuracy of predicting subcellular localization of Gram-positive bacterial proteins. Our approach performed well on a five-fold cross validation with an overall success rate of 89.5%. Besides, the overall success rate of an independent testing dataset was 97.7%. Moreover, our approach was tested using a new experimentally-determined set of Gram-positive bacteria proteins and achieved an overall success rate of 96.3%.


► We introduce a novel approach based on localization motifs to improve the predicting accuracy.
► We introduce a novel position-specific frequency encoding approach.
► Our approach greatly improved the accuracy of prediction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 308, 7 September 2012, Pages 135–140
نویسندگان
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