A generalization of substitution evolution models of nucleotides to genetic motifs

► Generalization of stochastic substitution models of nucleotides. ► Determination of analytical occurrence probabilities of genetic motifs at time t. ► Evolution direction either direct (past-present) or inverse (present-past). ► Kronecker relation between substitution matrices of nucleotides and motifs. ► Development of the SEGM (Stochastic Evolution of Genetic Motifs) web server.