کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4496896 1623921 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Deformation and reperfusion damages and their accumulation in subcutaneous tissues during loading and unloading: A theoretical modeling of deep tissue injuries
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم کشاورزی و بیولوژیک (عمومی)
پیش نمایش صفحه اول مقاله
Deformation and reperfusion damages and their accumulation in subcutaneous tissues during loading and unloading: A theoretical modeling of deep tissue injuries
چکیده انگلیسی

Deep tissue injuries (DTI) involve damages in the subcutaneous tissues under intact skin incurred by prolonged excessive epidermal loadings. This paper presents a new theoretical model for the development of DTI, broadly based on the experimental evidence in the literatures. The model covers the loading damages implicitly inclusive of both the direct mechanical and ischemic injuries, and the additional reperfusion damages and the competing healing processes during the unloading phase. Given the damage accumulated at the end of the loading period, the relative strength of the reperfusion and the healing capacity of the involved tissues system, the model provides a description of the subsequent damage evolution during unloading. The model is used to study parametrically the scenario when reperfusion damage dominates over healing upon unloading and the opposite scenario when the loading and subsequent reperfusion damages remain small relative to the healing capacity of the tissues system. The theoretical model provides an integrated understanding of how tissue damage may further build-up paradoxically even with unloading, how long it would take for the loading and reperfusion damages in the tissues to become fully recovered, and how such loading and reperfusion damages, if not given sufficient time for recovery, may accumulate over multiple loading and unloading cycles, leading to clinical deep tissues ulceration.


► A damage model to describe the development of deep injury due to skin loading.
► Includes both the loading damages and the reperfusion damages during unloading.
► Includes healing competing with the reperfusion damage process during unloading.
► Damage can rise upon unloading before healing finally catches up.
► Predicts the accumulated damage over multiple cycles of loading–unloading.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Theoretical Biology - Volume 289, 21 November 2011, Pages 65–73
نویسندگان
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