Human microRNA target identification by RRSM

► miRNAs are small non-coding RNAs that regulate mRNAs in various biological processes. ► We focus on the human miRNA target prediction. ► We propose a generalized relative R2 method (RRSM) to find high-confidence targets. ► Many targets selected by RRSM have been confirmed from previous studies. ► Several miRNA targets discovered by the HITS-CLIP method are also selected by our study.