کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4497193 | 1318920 | 2011 | 11 صفحه PDF | دانلود رایگان |
Bursting oscillations are common in neurons and endocrine cells. One type of bursting model with two slow variables has been called ‘phantom bursting’ since the burst period is a blend of the time constants of the slow variables. A phantom bursting model can produce bursting with a wide range of periods: fast (short period), medium, and slow (long period). We describe a measure, which we call the ‘dominance factor’, of the relative contributions of the two slow variables to the bursting produced by a simple phantom bursting model. Using this tool, we demonstrate how the control of different phases of the burst can be shifted from one slow variable to another by changing a model parameter. We then show that the dominance curves obtained as a parameter is varied can be useful in making predictions about the resetting properties of the model cells. Finally, we demonstrate two mechanisms by which phase-independent resetting of a burst can be achieved, as has been shown to occur in the electrical activity of pancreatic islets.
Journal: Journal of Theoretical Biology - Volume 276, Issue 1, 7 May 2011, Pages 218–228